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dietary
supplements
98% ultra-pure trans-resveratrol
dietary
supplements
98% ultra-pure trans-resveratrol
Anti-Inflammatory Joint Comfort
Joint stiffness isn't just wear and tear. Here's what's actually happening — and five compounds that address it.
The aches and stiffness that creep in with age aren't only mechanical. Underneath, a quiet, chronic inflammation is breaking down the tissue your joints depend on. Five plant compounds — in one daily formula — work on that, at the source.
You don't have to know the science to feel the difference between a joint that moves easily and one that doesn't. Start with what's happening — we'll explain the rest.
address inflammation where it starts
9 TARGETED COMPOUNDS • 90 VEGETABLE CAPSULES • MADE IN THE USA
BACKED BY 35 YEARS • 60-DAY GUARANTEE
Anti-Inflammatory Joint Comfort
Joint stiffness isn't just wear and tear. Here's what's actually happening — and five compounds that address it.
The aches and stiffness that creep in with age aren't only mechanical. Underneath, a quiet, chronic inflammation is breaking down the tissue your joints depend on. Five plant compounds — in one daily formula — work on that, at the source.
You don't have to know the science to feel the difference between a joint that moves easily and one that doesn't. Start with what's happening — we'll explain the rest.
address inflammation where it starts
9 TARGETED COMPOUNDS • 90 VEGETABLE CAPSULES • MADE IN THE USA
BACKED BY 35 YEARS • 60-DAY GUARANTEE
what’s happening
It's easy to call it "getting
older." The real story is
happening in the tissue.
Stiff mornings, aches after sitting too long, joints that don't move the way they used to — it's tempting to write it all off as simple wear and tear. But research increasingly points to another driver underneath: chronic, low-grade inflammation. Over time, inflammatory signaling (driven by molecules like IL-1β) keeps the body in a state of constant low activation, and that quietly accelerates the breakdown of cartilage and connective tissue — the very tissue that keeps joints cushioned and moving freely. Researchers now consider this low-grade inflammation a key driver of how joints age.
That's an important shift, because it means there's something to work on — not just a mechanical problem to wait out. The idea behind this formula isn't a topical that numbs the surface; it's a deliberate stack of compounds, each studied for a different part of the inflammatory and oxidative process that wears joints down.
Here are the five — and we'll start each one with the joint, not the chemistry.
COMPOUND 1
Trans-Resveratrol
98% pure · from Japanese Knotweed · 600 mg
the joint angle
The deep, persistent stiffness that surface treatments never quite reach.
Topicals work on the surface. Resveratrol works where the inflammation actually begins — inside the cell. In laboratory studies on human cartilage cells, resveratrol suppressed the IL-1β–induced inflammatory signaling (the NF-κB pathway) that drives cartilage breakdown — and did so in synergy with curcumin.2 And the form matters: trans-resveratrol is the bioactive, well-absorbed form research is built on,3 which is why this formula uses 98% ultra-pure trans-resveratrol from research-grade Japanese knotweed, not cheap grape-skin extract.
Why it matters for you: it addresses the source of joint inflammation, not just the sensation of it.
You don't have to know the science to feel the difference between a joint that moves easily and one that doesn't. Start with what's happening — we'll explain the rest.
COMPOUND 2
Organic Turmeric (Curcumin)
100 MG
the joint angle
The everyday ache and stiffness that makes movement feel like work.
Turmeric is the most-studied botanical for joint comfort, and the human evidence is real: a systematic review and meta-analysis of randomized controlled trials found that curcumin (turmeric's active compound) reduced pain and improved physical function in people with knee osteoarthritis.4 It works by calming the same inflammatory pathways that drive cartilage breakdown.
Why it matters for you: this is the compound with the strongest track record for how joints actually feel day to day.
"The one botanical that's been tested, head-to-head, for how joints feel — and held up."
COMPOUND 3
French Maritime Pine Bark
Pinus pinaster · 100 mg
the joint angle
Stiffness and pain that flare with use.
Pine bark is one of the few plant extracts tested directly in joint research. In a randomized, double-blind, placebo-controlled trial in people with knee osteoarthritis, French maritime pine bark extract improved WOMAC scores and significantly reduced pain over three months.5 Its proanthocyanidins are studied for both antioxidant action and calming inflammatory signaling.
Why it matters for you: a plant compound with human joint-trial evidence behind it — not just promise.
"One of the few plant extracts tested directly in knee-joint trials — and it moved the needle."
COMPOUND 4
Pomegranate Extract
300 MG
the joint angle
The slow erosion you can't feel happening — until you can.
Cartilage doesn't regenerate easily, so protecting it matters. In laboratory studies on human cartilage cells, pomegranate extract inhibited the IL-1β–induced, cartilage-degrading enzymes (matrix metalloproteinases) that break tissue down — by blocking the inflammatory signaling that switches them on.6 Its polyphenols (ellagic acid) also provide targeted antioxidant support against the oxidative stress that accelerates breakdown.
Why it matters for you: the goal isn't only to feel better today — it's to protect the tissue your joints depend on.
"Cartilage doesn't grow back easily. This helps slow what breaks it down."
COMPOUND 5
Quercetin
200 mg
the joint angle
Stiffness as the first visible sign of inflammation that's affecting more than your joints.
Joints are often where systemic inflammation shows up first. Quercetin, a dietary flavonoid, works across multiple inflammatory pathways at once: in a randomized controlled trial, quercetin supplementation significantly reduced morning stiffness and pain in adults with inflammatory joint disease, and laboratory research shows it helps protect cartilage by tempering the same inflammatory and oxidative signals seen in joint breakdown.
Why it matters for you: addressing the systemic inflammation underneath, not just the joint it surfaced in.
"Joint stiffness is often the first sign. Quercetin addresses what's underneath it."
COMPOUND 1
Trans-Resveratrol
98% pure · from Japanese Knotweed · 600 mg
the joint angle
The deep, persistent stiffness that surface treatments never quite reach.
Topicals work on the surface. Resveratrol works where the inflammation actually begins — inside the cell. In laboratory studies on human cartilage cells, resveratrol suppressed the IL-1β–induced inflammatory signaling (the NF-κB pathway) that drives cartilage breakdown — and did so in synergy with curcumin.2 And the form matters: trans-resveratrol is the bioactive, well-absorbed form research is built on,3 which is why this formula uses 98% ultra-pure trans-resveratrol from research-grade Japanese knotweed, not cheap grape-skin extract.
Why it matters for you: it addresses the source of joint inflammation, not just the sensation of it.
You don't have to know the science to feel the difference between a joint that moves easily and one that doesn't. Start with what's happening — we'll explain the rest.
COMPOUND 2
Organic Turmeric (Curcumin)
100 MG
the joint angle
The everyday ache and stiffness that makes movement feel like work.
Turmeric is the most-studied botanical for joint comfort, and the human evidence is real: a systematic review and meta-analysis of randomized controlled trials found that curcumin (turmeric's active compound) reduced pain and improved physical function in people with knee osteoarthritis.4 It works by calming the same inflammatory pathways that drive cartilage breakdown.
Why it matters for you: this is the compound with the strongest track record for how joints actually feel day to day.
"The one botanical that's been tested, head-to-head, for how joints feel — and held up."
COMPOUND 3
French Maritime Pine Bark
Pinus pinaster · 100 mg
the joint angle
Stiffness and pain that flare with use.
Pine bark is one of the few plant extracts tested directly in joint research. In a randomized, double-blind, placebo-controlled trial in people with knee osteoarthritis, French maritime pine bark extract improved WOMAC scores and significantly reduced pain over three months.5 Its proanthocyanidins are studied for both antioxidant action and calming inflammatory signaling.
Why it matters for you: a plant compound with human joint-trial evidence behind it — not just promise.
"One of the few plant extracts tested directly in knee-joint trials — and it moved the needle."
COMPOUND 4
Pomegranate Extract
300 MG
the joint angle
The slow erosion you can't feel happening — until you can.
Cartilage doesn't regenerate easily, so protecting it matters. In laboratory studies on human cartilage cells, pomegranate extract inhibited the IL-1β–induced, cartilage-degrading enzymes (matrix metalloproteinases) that break tissue down — by blocking the inflammatory signaling that switches them on.6 Its polyphenols (ellagic acid) also provide targeted antioxidant support against the oxidative stress that accelerates breakdown.
Why it matters for you: the goal isn't only to feel better today — it's to protect the tissue your joints depend on.
"Cartilage doesn't grow back easily. This helps slow what breaks it down."
COMPOUND 5
Quercetin
200 mg
the joint angle
Stiffness as the first visible sign of inflammation that's affecting more than your joints.
Joints are often where systemic inflammation shows up first. Quercetin, a dietary flavonoid, works across multiple inflammatory pathways at once: in a randomized controlled trial, quercetin supplementation significantly reduced morning stiffness and pain in adults with inflammatory joint disease, and laboratory research shows it helps protect cartilage by tempering the same inflammatory and oxidative signals seen in joint breakdown.
Why it matters for you: addressing the systemic inflammation underneath, not just the joint it surfaced in.
"Joint stiffness is often the first sign. Quercetin addresses what's underneath it."
Why one formula
Five compounds, or one
formula with nine.
You could chase all of this down separately. Research-grade trans-resveratrol from Japanese knotweed. Standardized grape seed. French maritime pine bark. Quercetin. Cinnamon. That's five different bottles, five different brands, five different purity standards — and no guarantee any of them are using the forms the research is actually based on.
And we didn't stop at five. The full formula carries nine targeted compounds in a single daily serving — 1,750 mg, in 90 vegetable capsules — formulated by a brand that has been doing exactly this for 35 years. Clean, non-GMO, vegan, lab-tested, and made in the USA.
9
targeted
compounds
1,750 mg
Per daily
serving
35
Years of formulation
One capsule routine a day, working at the source.
address inflammation where it starts
Why one formula
Five compounds, or one formula with nine.
Each of these addresses a different piece of why joints stiffen and ache with age. Resveratrol at the cellular source. Turmeric for how joints feel. Pine bark with human joint-trial evidence. Pomegranate to help protect cartilage. Quercetin for the inflammation underneath. Track them down individually and you'd be managing five separate supplements, with five separate price tags — and no way to know if any of them use the forms the research is built on.
Or you take the one formula that already has them — and four more. Resveratrol Plus® carries nine targeted compounds in a single daily serving, 1,750 mg in 90 vegetable capsules, from a brand that's been formulating supplements like this for 35 years. Clean, non-GMO, vegan, lab-tested, made in the USA.
9
targeted compounds
1,750 mg
Per daily serving
35
Years of formulation
One capsule routine a day, working at the source.
address inflammation where it starts
Resveratrol Plus®
Address inflammation
where it starts.
90 VEGETABLE CAPSULES • FROM $41.99 • 60-DAY MONEY BACK GUARANTEE
$41.99
30-day supply
vegan capsules
•
lab tested
•
doctor formulated
•
98% trans-resveratrol
•
made in the usa
vegan capsules
•
lab tested
•
doctor formulated
•
98% trans-resveratrol
•
made in the usa
•
“Cardiovascular support is not about one ingredient or one quick result — it’s about consistent daily support from clean, well-sourced compounds that work together over time.”
Denys Tsveiuk
Medical Doctor, Certified Nutritional Therapist & Chief Science Officer to SupplementMD app.
references
Harrison DG, Gongora MC. Oxidative stress and hypertension. Med Clin North Am. 2009;93(3):621–635.
Linus Pauling Institute, Micronutrient Information Center. Resveratrol. Oregon State University.
Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187–17195.
Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin Nutr. 2015;34(1):27–34.
Feringa HHH, Laskey DA, Dickson JE, Coleman CI. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011;111(8):1173–1181.
Nishioka K, et al. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertens Res. 2007;30(9):775–780.
Serban MC, et al. Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016;5(7):e002713.
Cinnamon supplementation and metabolic outcomes: an umbrella review of meta-analyses of randomized controlled trials. 2025.
IMPORTANT
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Cited studies refer to the individual compounds and do not represent claims about this finished product.
2026 © Nora Ross, Inc.